A My NCBI account allows you to save PubMed searches and set up automatic e-mail alerts. In addition, you can use your My NCBI account to save citations into Collections, see the PubMed My NCBI pamphlet for more instruction and a description of all features.
In PubMed, to save your search strategy and create search alerts, follow these easy steps:
Viewing and Editing Saved Searches
You will be able to view your saved searches and alerts from your My NCBI account. In the "Saved Searches" box will be a listing of the searches you have saved. Click the "gear" icon to view and/or edit the search strategy or update frequency. To view a complete list of saved searches and their update schedule, click Manage Saved Searches.